previous  nextU54777.C8.3324 (MSH6) -> ENSG00000116062@66_37.C8.48030640
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Tract / statusC8 / cMNR -> Tx!   MNR_ensembl
First published byPAPADOPOULOS1995 PubMed
Accession numberU54777 gi:6063478
Gene (chromosome)MSH6  ( 2 )   SOURCE
alt. namesMSH6;GTBP
EnsemblENSG00000116062   SMART   GermOnline   GeneCards
NCBIEntrez Gene 2956   Unigene Hs.445052 (SAGE)   GeneCards 2956 

Mutation rate [%] Colon Endometrium Stomach Urothel
Cancer Adenoma Culture Cancer Cancer Cancer
23.937.015.827.2
(n=1508)(n=27)(n=373)(n=555)

Genomic sequence
BLAST WWW
BLAST local
CCTATAAAAC ACTTAGGCTG ATAAAACCCC CAAACGATGA AGCCTCACTT TTACCCTCTC TTTTAACAGA TGTTTTACTG TGCCTGGCTA ACTATAGTCG AGGGGGTGAT GGTCCTATGT GTCGCCCAGT AATTCTGTTG CCGGAAGATA CCCCCCCCTT CTTAGAGCTT AAAGGATCAC GCCATCCTTG CATTACGAAG ACTTTTTTTG GAGATGATTT TATTCCTAAT GACATTCTAA TAGGCTGTGA GGAAGAGGAG CAGGAAAATG GCAAAGCCTA TTGTGTGCTT GTTACTGGAC CAAATATG
MNR, transcribed, primer.
PCR system1sense gggTgATggTCCTATgTgTC, antisense CgTAATgCAAggATggCgT, product length 94, Ta 60.
Transcript sequenceGACTGTTCTA TAACTTTGAT AAAAATTACA AGGACTGGCA GTCTGCTGTA GAGTGTATCG CAGTGTTGGA TGTTTTACTG TGCCTGGCTA ACTATAGTCG AGGGGGTGAT GGTCCTATGT GTCGCCCAGT AATTCTGTTG CCGGAAGATA CCCCCCCCTT CTTAGAGCTT AAAGGATCAC GCCATCCTTG CATTACGAAG ACTTTTTTTG GAGATGATTT TATTCCTAAT GACATTCTAA TAGGCTGTGA GGAAGAGGAG CAGGAAAATG GCAAAGCCTA TTGTGTGCTT GTTACTGGAC CAAATATG
MNR, homologue to genomic MNR region.
Transcripts#ENSTtranscribedtranslatedATGSTOPlengthMNRENSPlocate
1ENST0000023442011153423643283406ENSP00000234420show
2ENST000004455031015363641583236ENSP00000405294show
3ENST0000045624600107422846ENSP00000410570show
4ENST0000049317700813--
5ENST0000045538300232583578ENSP00000397484show
6ENST0000042081300189495491ENSP00000390382show
7ENST000004118190096552548ENSP00000406248show
8ENST000005400211152374538292915ENSP00000446475show
9ENST000005448570015333543353ENSP00000442745show
10ENST0000044625500153912908ENSP00000413366show
11ENST0000053813611794397140553141ENSP00000438580show
12ENST00000543270113249422443083406ENSP00000445199show
Shown are all Ensembl transcripts (ENSTs) currently annotated for the respective Ensembl gene (ENSG), Ensembl rel. 66_37.
final status: cMNR (cMNR) .

Culture data cell line   mutated   allele(s)  reference
Co115 1 m1wt WOERNER2001
Colo60H 0 wt WOERNER2001
DLD1 0 - PAPADOPOULOS1995
HCT116 1 wtp1 WOERNER2001
HCT15 0 - PAPADOPOULOS1995
HCT8/HRT18 0 - KU1999
KM12 1 wtp1p2 WOERNER2001
LoVo 0 - MALKHOSYAN1996A
LS174T 1 m1wt* MALKHOSYAN1996A / *WOERNER2001
LS180 1 m1wt* MALKHOSYAN1996A / *WOERNER2001
LS411 0 - MALKHOSYAN1996A
RKO 0 wt WOERNER2001
SNU-1040 0 - KU1999
SNU-1047 0 - KU1999
SNU-175 0 - KU1999
SNU-407 0 - KU1999
SNU-769A 1 - KU1999
SNU-769B 0 - KU1999
SNU-C2A 1 p1* KU1999 / *YOU2007
SNU-C4 1 m1wt* KU1999 / *YOU2007
SW48 1 wtp1* MALKHOSYAN1996A / *WOERNER2001
TC7 1 mwt* GAYET2001 / *ELBCHIRI2005
TC71 0 - GAYET2001

Show consequences concerning peptide sequence(s) of frameshift alleles m2/m1/p1/p2.


1 primers derived from MALKHOSYAN1996A.

SelTarbase version latest, release 201307, last updated 20130701.

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