previous  nextJ04810.A8.1202 (MSH3) -> ENSG00000113318@66_37.A8.79970915
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Tract / statusA8 / cMNR -> Tx!   MNR_ensembl
First published byMALKHOSYAN1996A PubMed
Accession numberJ04810 gi:181841
Gene (chromosome)MSH3  ( 5 )   SOURCE
alt. namesMSH3
EnsemblENSG00000113318   SMART   GermOnline   GeneCards
NCBIEntrez Gene 4437   Unigene Hs.280987 (SAGE)   GeneCards 4437 

Mutation rate [%] Colon Endometrium Stomach Urothel
Cancer Adenoma Culture Cancer Cancer Cancer
42.053.119.438.9
(n=1561)(n=32)(n=341)(n=586)

Genomic sequence
BLAST WWW
BLAST local
ATTTAGCATA TAATTATTTT TCTTTAATTA TTATTAAATG TGAATCCCCT AATCAAGCTG GATGATGCTG TAAATGTTGA TGAGATAATG ACTGATACTT CTACCAGCTA TCTTCTGTGC ATCTCTGAAA ATAAGGAAAA TGTTAGGGAC AAAAAAAAGG GCAACATTTT TATTGGCATT GTGGTAAGTA CTTTGCAGGT GAGGAACAAA TGTTAGATGT TCATGGTATC TCTAAATATG ATCTATCATG TATGGTTTAT AATAAGGATA TCTGATGAAG TGTACCTTCA GATAATTATA CAAGAAAA
MNR, transcribed, primer.
PCR system1sense AgATgTgAATCCCCTAATCAAgC, antisense ACTCCCACAATgCCAATAAAAAT, product length 147, Ta 57.
Transcript sequenceACTGCCCTTT ATACAAAATC TACACTTATT GGAGAAGATG TGAATCCCCT AATCAAGCTG GATGATGCTG TAAATGTTGA TGAGATAATG ACTGATACTT CTACCAGCTA TCTTCTGTGC ATCTCTGAAA ATAAGGAAAA TGTTAGGGAC AAAAAAAAGG GCAACATTTT TATTGGCATT GTGGGAGTGC AGCCTGCCAC AGGCGAGGTT GTGTTTGATA GTTTCCAGGA CTCTGCTTCT CGTTCAGAGC TAGAAACCCG GATGTCAAGC CTGCAGCCAG TAGAGCTGCT GCTTCCTTCG GCCTTGTC
MNR, homologue to genomic MNR region.
Transcripts#ENSTtranscribedtranslatedATGSTOPlengthMNRENSPlocate
1ENST000002650811181349540921221ENSP00000265081show
2ENST0000051253100531--
3ENST0000051225800677--
4ENST00000535995111338843371114ENSP00000440204show
Shown are all Ensembl transcripts (ENSTs) currently annotated for the respective Ensembl gene (ENSG), Ensembl rel. 66_37.
final status: cMNR (cMNR) .

Culture data cell line   mutated   allele(s)  reference
Co115 1 m1wt WOERNER2001
Colo60H 1 m1wt WOERNER2001
DLD1 0 - MALKHOSYAN1996A
HCA7 1 m1 WILLIAMS2010
HCT116 1 m1* IKEDA1998 / *WOERNER2001
HCT15 0 - MALKHOSYAN1996A
HCT8/HRT18 0 - KU1999
KM12 1 m1wt WOERNER2001
LIM1215 1 m1wt WILLIAMS2010
LIM1899 0 wt WILLIAMS2010
LIM2405 1 m1wt WILLIAMS2010
LIM2408 1 m1wt WILLIAMS2010
LIM2537 0 wt WILLIAMS2010
LIM2550 0 wt WILLIAMS2010
LIM2551 0 wt WILLIAMS2010
LoVo 0 - MALKHOSYAN1996A
LS174T 0 - MALKHOSYAN1996A
LS180 0 - MALKHOSYAN1996A
LS411 1 - MALKHOSYAN1996A
RKO 1 m1wt WOERNER2001
SNU-1040 1 - KU1999
SNU-1047 1 - KU1999
SNU-175 0 - KU1999
SNU-407 0 - KU1999
SNU-769A 1 - KU1999
SNU-769B 1 - KU1999
SNU-C2A 0 - KU1999
SNU-C4 1 m1* KU1999 / *YOU2007
SW48 0 - MALKHOSYAN1996A
TC7 1 mwt* GAYET2001 / *ELBCHIRI2005
TC71 0 - GAYET2001
VaCo481 1 - MA2000B

Show consequences concerning peptide sequence(s) of frameshift alleles m2/m1/p1/p2.


1 primers derived from MALKHOSYAN1996A.

SelTarbase version latest, release 201307, last updated 20130701.

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